The latest news about the CMCiB. For more news of research at the IGTP, please see our main website.
A new e-book published by the Journal Laboratory Equipment, called Safe and Effective Research in the Vivarium features a case study from the Centre for Comparative Medicine and Bioimage of the IGTP (CMCiB-IGTP). Staff from the CMCiB have provided expert advice on aspects of safety.
Mireia Ramos Rodríguez is awarded the prize for the Best Research Paper by a Predoctoral Student by the Catalan Institute of Health
Mireia Ramos Rodríguez is a bioinformatics post-doctoral researcher; she focusses on defining the changes in cis-regulatory elements that can lead to the development of disease and programming to provide tools for other researchers to carry out their analyses. She has been awarded the Prize for Best Research Paper in Health by a Predoctoral Researcher for her article published in Nature Genetics.
The Centre for Comparative Medicine and Bioimage of Catalonia (CMCiB), of the Germans Trias i Pujol Research Institute (IGTP), will be the second centre in Catalonia to work on the SARS-CoV-2 virus obtained directly from patients. Until now most work has taken place with artificial viruses that can only infect once. Research staff of IrsiCaixa and the Institute of Evolutionary Biology (IBE) have started to work on the virus in the CMCiB to study the infection of organoids; mini organs designed in the laboratory to simulate human lungs and brains. Organoids are already being used in research and their use in studies into COVID-19 will provide better understanding of infection by SARS-CoV-2 and the capacity of different drugs to eliminate it from these tissues.
A review paper with first author Marc Melià-Sorolla of the Cellular and Molecular Neurobiology Research Group and published in the International Journal of Molecular Sciences highlights a porcine model as the most suitable for stroke research in the future. The CMCiB-IGTP is equipped to carry out this type of research and the group led by Teresa Gasull are already showing the potential of the non-invasive bioimaging technology.
The Centre for Comparative medicine and Bioimage (CMCiB) of the IGTP has its level 3 biological containment laboratories (BCLL3) ready to receive new projects related to the study of the SARS-CoV-2 virus. These facilities are biological containment areas designed for work on microorganisms that cause infectious diseases, especially those with a high risk of transmission through the diffusion of aerosols.
The study focusses on understanding the mechanisms that keep the infection latent without the infected person developing the disease. 90% of people infected never develop the active disease, understanding this mechanism so that we can identify them is key to eradicating tuberculosis. The research has been carried out in virtual lungs, developed by computational modelling techniques. These are the first results to be published by the 3Rs Programme at the Centre for Comparative Medicine and Bioimage (CMCiB) which aims to minimize the use of animals in pre-clinical research.