The year 2025 was particularly significant for the Germans Trias i Pujol Research Institute (IGTP). Coinciding with its 30th anniversary, the Institute continued to advance in the generation of biomedical knowledge with an impact on health, strengthening its links with the healthcare system, promoting innovation, and maintaining a strong commitment to society. This article offers an overview of the most relevant news from the year, reflecting the diversity and robustness of IGTP's scientific and institutional activity.

Health-impact research

Research carried out at IGTP throughout 2025 continued to address key clinical challenges, with a clear translational focus and a close connection to clinical practice.

In the field of rare diseases and cancer, a study identified a new triple combination of inhibitors based on precision medicine as a potential treatment for malignant peripheral nerve sheath tumours, a highly aggressive type of cancer with limited therapeutic options. The results open the door to new therapeutic strategies tailored to patients' molecular profiles.

In the area of neuromuscular diseases, the DM1-Hub project was launched as a pioneering national network aimed at transforming research and care for myotonic dystrophy type 1. This national, multicentre study lays the groundwork for improving knowledge of the disease and harmonising clinical care, while strengthening collaboration between centres across Spain.

The international projection of IGTP's research was reflected in the publication of a study in Nature Communications analysing, for the first time, the relationship between the transcriptomics of tuberculosis lesions and patients' clinical parameters. Led by researchers from the Institute, the study provides new evidence of the association between the inflammatory profile of lesions and clinical prognosis, with relevant implications for disease management.

The clinical impact of research was also particularly evident in the field of inflammatory bowel disease. A study led by the CIBEREHD group at Hospital Germans Trias demonstrated, for the first time, that it is possible to reduce the number of colonoscopies and improve follow-up in patients with Crohn's disease, optimising healthcare resources without compromising quality of care.

Finally, in the context of the long-term consequences of the pandemic, a large-scale genetic study involving the GCAT project identified the FOXP4 gene as the first to be associated with long COVID. This finding, published in Nature Genetics, represents an important step forward in understanding the biological mechanisms of the condition and opens new avenues for future research.

A year of institutional consolidation and the 30th anniversary

The year 2025 was marked by the celebration of IGTP's 30th anniversary, an opportunity to highlight three decades of research, collaboration and commitment to health.

In this context, IGTP held its annual symposium under the banner of the 30th anniversary, bringing together professionals from research, healthcare and management to reflect on the Institute's trajectory and future challenges. The anniversary was also marked by an institutional and Christmas event held on 11 December at the BCIN, conceived as a space for recognition, collective memory and future projection. The event highlighted IGTP's trajectory and the strength of its community. Both activities served to underline IGTP's role as a key actor within the Campus Can Ruti and the Catalan biomedical research system, as well as its contribution to the transfer of knowledge into clinical practice.

This institutional momentum was further reinforced by the visit of the Minister for Research and Universities, Núria Montserrat, who gained first-hand insight into the health research and innovation projects being developed at the Institute. The visit highlighted IGTP's relevance as a biomedical research centre closely linked to its territory and fully integrated within the country's scientific and healthcare ecosystem.

Innovation and knowledge transfer

Innovation remained a strategic pillar of IGTP's activity throughout 2025, with initiatives aimed at facilitating knowledge transfer and fostering collaboration with the productive sector.

The Innomed programme consolidated its second edition with the Innomed Awards, which recognised fifteen innovative biomedical projects and highlighted initiatives with potential for transfer and impact on health. Throughout the year, the Innomed community promoted activities designed to strengthen collaboration between research, clinical practice and industry, including a joint workshop with Leitat to promote health innovation and a visit to the Immunoassay Technology Center, Werfen's facilities in Lliçà d'Amunt. These activities enabled participating teams to become familiar with technological resources and explore synergies with external stakeholders.

In parallel, IGTP secured more than €13 million to support the development of research projects and strengthen research talent. This funding contributes to ensuring the sustainability of the Institute's scientific activity and to promoting new research lines with potential health impact.

Commitment to outreach and society

Scientific outreach and educational engagement once again played a prominent role in IGTP's activities. As part of Science Week, students from Badalona had the opportunity to discover the research carried out at Campus Can Ruti, visiting laboratories and learning first-hand about the work of researchers.

In addition, throughout the year, several female researchers from IGTP took part in activities in schools, bringing science into the classroom and helping to inspire scientific vocations among younger generations, including the seventh edition of #científiques and Ciència al carrer: Fira d'ESO amb mirada STEAM. These initiatives reinforce the Institute's commitment to society and to promoting scientific knowledge as a driver of progress.

Looking ahead

Overall, 2025 consolidated IGTP's position as a leading biomedical research institute. The milestones achieved in research, innovation, outreach and institutional activity reflect a model based on collaboration, scientific excellence and impact on health. Looking to the future, IGTP approaches the coming years with a firm commitment to continuing to generate knowledge in the service of people.

These news items represent a selection from a year of intense activity, marked by numerous achievements in research, innovation, outreach and institutional action, which have collectively contributed to strengthening IGTP's role as a reference biomedical research institute.